In inflationary cosmology, primordial quantum fluctuations in the process of inflation are considered responsible for the asymmetry and lumpiness of the universe that was shaped. However, according to the Copenhagen interpretation, any random quantum phenomenon only occurs when the system is observed; before observation, the quantum state is symmetric. So the question is, who has observed the universe while it was inflating? Obviously, there was no conscious creature that time.
Actually, this problem is discussed in the paper The Bohmian Approach to the Problems of Cosmological Quantum Fluctuations (Goldstein, Struyve and Tumulka; arXiv:1508.01017), and the proposed solution to the problem in said to be an observer-independent interpretation (the pilot-wave theory).